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StemRD  RSPO-100 R-spondin-1, human

产品编号  RSPO-100| StemRD

R-spondin-1, 人

产品描述

R-spondin-1 (RSPO-1) is a natural enhancer of the canonical WNT pathway. When used together with WNT proteins that activate the

beta-catenin pathway, R-spondin-1 enhances the activity of canonical WNT proteins by binding to LGR5 and LGR4 (refs.)

Injection of recombinant R­Spondin-1 into mouse causes  activation of the β­catenin pathway and proliferation of intestinal crypt cells, which forms the basis for a clinical trial in amelioration of chemotherapy-induced colitis.  

The Predicted MW of full-length R-Spondin-1 is 25.6 kDa, and due to glycosylation it runs on SDS­PAGE at ~39 kDa under

reducing conditions. StemRD’s R-Spondin-1 is produced in human 293 cells as a secreted protein (without tag) and purified by a series of chromatography.

Refs:  de Lau, et al, LGR5 homologues associate with Wnt receptors and mediate R-spondin signaling.  Nature. 2011 July 4; 476: 293;  

Carmon, et al, R-spondins function as ligands for the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling. PNAS. 2011 Jul 12; 108: 11452.

公司简介

StemRD Inc. is located in the San Francisco Bay Area, we specialize in producing premier research reagents for the stem cell research community. Our mission is to empower stem cell R&D through innovative technologies. Our proprietary technology in protein expression and purification has allowed efficient production of several important factors, such as WNT, Hedgehog, TGF-ß family members and Differentiation Kits, that are difficult to obtain by conventional methods.

StemRD 是美国一家聚焦于尖端干细胞研究的公司，拥有蛋白表达和纯化方面的专利技术。拥有被美国FDA认证的可用于GMP生产治疗型多肽的设施。StemRD的实验室拥有包括组织培养、细胞处理、超离心、超过滤、FPLC、HPLC和LC/MS等一系列先进设备。其中干细胞研究用生长/分化因子、小分子化合物均包括目前研究较多的WNT/β-catenin、TGF-β、Hedgehog、Notch等信号通路等。

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重庆市寰宇安泰生物科技有限公司

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