Anti-Hu CD4, OKT4, AD, 25 60016AD.1 25 tests

Product Overview

The OKT4 antibody reacts with CD4, an ~59 kDa single-chain type 1 transmembrane glycoprotein and member of the immunoglobin (Ig) superfamily; CD4 contains four extracellular Ig-like domains (D1 – D4). The epitope for OKT4 has been localized to the D3 domain of the protein, which has a structure resembling an Ig variable domain. CD4 is expressed at relatively high levels by most thymocytes and a subpopulation of T cells (T-helper cells), and at lower levels by peripheral blood monocytes and macrophages. CD4 binds to a non-polymorphic region of MHC II and acts as a co-receptor to the T cell receptor (TCR) in MHC II-restricted antigen recognition by enhancing the affinity of the association between the TCR and MHC II-antigen complex. CD4 also functions to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck. Moreover, CD4 is a receptor for the human immunodeficiency virus (HIV). Binding of the OKT4 antibody to CD4 does not block HIV binding.

This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Direct Human CD4+ T Cell Isolation Kit (Catalog #19662), EasySep™ Human CD4+ T Cell Enrichment Kit (Catalog #19052), EasySep™ Human CD3 Positive Selection Kit (Catalog #18051) and EasySep™ Human CD4 Positive Selection Kit (Catalog #18052; partial blocking may be observed).

Subtype:一抗

Target Antigen:CD4

Reactive Species:黑猩猩; 食蟹猴; 人; 猕猴; 白颈白眉猴

Conjugation:Alexa Fluor 488; APC; 生物素; FITC; PE; PerCP-Cyanine5.5; 未结合

Host Species:小鼠

Cell Type:T细胞; CD4+T细胞; 调节性T细胞

Application:流式细胞术; 功能检测; 免疫荧光; 免疫组化; 免疫沉淀

Area of Interest:免疫学; 移植研究

Clone:OKT4

Gene ID:920

Isotype:IgG2b, kappa

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