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Stemcell  60004FI  Anti-Human CD14 Antibody, Clone M5E2

Product Overview

The M5E2 antibody reacts with CD14, an ~53 - 55 kDa GPI-anchored transmembrane glycoprotein expressed at high levels on the surface of peripheral blood monocytes and macrophages, and at lower levels on granulocytes. An ~10-fold difference in expression levels between monocytes/macrophages and granulocytes makes CD14 a useful marker for distinguishing these cell populations. CD14 is also found on tissue macrophages, Langerhans cells and dendritic cells. CD14 functions as a high-affinity receptor for complexes of lipopolysaccharide (LPS) and serum LPS-binding protein and modulates LPS-dependent signal transduction during the immune response to gram-negative pathogens by acting as a co-receptor for TLR 4 and MD-2. This triggers activation of NF-kappa-B, cytokine secretion, and induction of the inflammatory response. Two soluble forms of CD14 have also been described (~48 and ~55 kDa).

This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Human Myeloid Positive Selection Kit (Catalog #18653) and EasySep™ Human CD14 Positive Selection Kit (Catalog #18058); partial blocking may be observed, as well as EasySep™ HLA Whole Blood CD33 Positive Selection Kit (Catalog #18287HLA), EasySep™ HLA Whole Blood Myeloid Positive Selection Kit (Catalog #18683HLA), and EasySep™ Human Buffy Coat CD14 Positive Selection Kit (Catalog #18088).

Subtype:一抗

Target Antigen:CD14

Reactive Species:卷尾猴; 普通狨猴; 绒顶柽柳猴; 食蟹猴; 猕猴; 松鼠猴; 黑猩猩; 牛; 狗; 人; 恒河猴; 猪; 羊

Conjugation:Alexa Fluor 488; APC; 生物素; FITC; PE; 未结合

Host Species:小鼠

Cell Type:单核细胞

Application:CyTOF; 流式细胞术; 功能检测; 免疫细胞化学; 免疫荧光; 免疫组化; 中和及阻滞

Area of Interest:免疫学

Clone:M5E2

Gene ID:929

Isotype:IgG2a, kappa

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