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Stemcell  60041AD  Anti-Human CD16 Antibody, Clone 3G8

Product Overview

The 3G8 antibody reacts with CD16 (FcγRIII or low affinity IgG receptor III), a type 1 transmembrane glycoprotein belonging to the Ig superfamily. CD16 exists in two distinct isoforms: CD16a, a 50 - 65 kDa form expressed on NK cells, activated monocytes, macrophages, and placental trophoblasts, and CD16b, an ~48 kDa glycosylphosphatidylinositol (GPI)-anchored form expressed on neutrophils, basophils and eosinophils and found as at least two polymorphic variants, termed NA1 and NA2. CD16 binds weakly to the Fc region of monomeric, aggregated or complexed IgG, particularly the IgG1 and IgG3 isotypes. Binding of IgG to either CD16 isoform induces signaling pathways that modulate several types of responses, including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, cytokine release and proliferation. CD16/IgG interactions can result in non-specific labeling in antibody-based detection and cell separation experiments and the 3G8 antibody may be employed as a blocking antibody to reduce non-specific binding.

Subtype:一抗

Target Antigen:CD16

Reactive Species:狒狒; 卷尾猴; 普通狨猴; 绒顶柽柳猴; 食蟹猴; 猕猴; 白颈白眉猴; 松鼠猴; 黑猩猩; 人; 恒河猴

Conjugation:Alexa Fluor 488; APC; 生物素; FITC; PE; 未结合

Host Species:小鼠

Cell Type:粒细胞及其亚型; 单核细胞

Application:细胞分离; CyTOF; 去除; ELISA; 流式细胞术; 功能检测; 免疫细胞化学; 免疫荧光; 免疫组化; 免疫沉淀; 中和及阻滞

Area of Interest:免疫学

Clone:3G8

Gene ID:2214

Isotype:IgG1, kappa

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