综合电商模板

Stemcell  60008AZ.1  Anti-Human CD20 Antibody, Clone 2H7

Product Overview

Antibody 2H7 reacts with CD20, an ~35 kDa non-glycosylated type 1 transmembrane protein in the MS4A protein family. The CD20 polypeptide transverses the cell membrane four times, with only a minor portion of the protein displayed on the cell surface. The epitope recognized by antibody 2H7 has been mapped to the amino acid sequence YNCEPANPSEKNSPST, located in the large extracellular loop of CD20. CD20 is expressed on pre-B cells, resting and activated B cells, some follicular dendritic cells, and a subset of T cells. Expression by B cells is lost upon their differentiation into plasma cells. By associating with several proteins, including the B cell receptor (CD79), MHC class I and II, CD53, CD81 and CD82, CD20 is involved in initiating intracellular signaling pathways that modulate the activation, proliferation and differentiation of B cells. It is thought that CD20 forms multi-subunit ion channels which regulate calcium ion flux across the plasma membrane. Activation of CD20 is accompanied by pronounced phosphorylation of the cytoplasmic domain of the ~33 kDa apo-protein, with the appearance of 35 - 37 kDa isoforms which associate with Src family kinases such as Fyn, Lck and Lyn.

This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Human Whole Blood CD20 Positive Selection Kit (Catalog #18685), EasySep™ Human CD19 Positive Selection Kit (Catalog #18054), and EasySep™ HLA Whole Blood Lymphoid Positive Selection Kit (Catalog #18684HLA).

Subtype:一抗

Target Antigen:CD20

Reactive Species:狒狒; 卷尾猴; 食蟹猴; 秘鲁夜猴; 猕猴; 松鼠猴; 黑猩猩; 人; 恒河猴

Conjugation:Alexa Fluor 488; APC; 生物素; FITC; PE; PerCP-Cyanine5.5; 未结合

Host Species:小鼠

Cell Type:B细胞

Application:细胞分离; CyTOF; ELISA; 流式细胞术; 免疫组化; 免疫沉淀

Area of Interest:嵌合体; HLA; 免疫学; 移植研究

Clone:2H7

Gene ID:931

Isotype:IgG2b, kappa

Related products

Uante,您的科研物资战略合作伙伴！

重庆市寰宇安泰生物科技有限公司