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Stemcell 60083PE Anti-Human CD22 Antibody, Clone HIB22
Product Overview
The HIB22 antibody reacts with CD22 (Siglec-2), a type I transmembrane glycoprotein expressed in the cytoplasm of pro-B and pre-B cells and on the surface of mature and activated B cells and B cell lymphomas, but not on plasma cells. CD22 functions as an inhibitory receptor for B cell receptor signaling and plays roles in modulating the activation threshold of B cells and controlling CD40 signaling. CD22 comprises two isoforms generated by alternative splicing: CD22α (~130 kDa) and CD22β (~140 kDa). Monomeric CD22β is the most abundant isoform but an αβ heterodimer is also expressed. CD22 is a member of the sialoadhesion subgroup within the immunoglobulin superfamily, with an N-terminal V-type Ig domain followed by six C2-type Ig domains. Binding of the HIB22 antibody reportedly requires the presence of the two N-terminal-most domains. Both the cytoplasmic and surface-bound forms of CD22 are recognized by the HIB22 antibody and its binding does not inhibit CD22-mediated cyto-adhesion.
Subtype:一抗
Target Antigen:CD22
Reactive Species:黑猩猩; 人
Conjugation:APC; FITC; PE; 未结合
Host Species:小鼠
Cell Type:B细胞
Application:ELISA; 流式细胞术; 功能检测; 免疫细胞化学; 免疫荧光; 免疫组化; 免疫沉淀
Area of Interest:免疫学
Clone:HIB22
Gene ID:933
Isotype:IgG1, kappa
Related products
Description | Catalog # | Format |
Anti-Hu CD22, HIB22, UC, 100µg | 60083 | 100 µg |
Anti-Hu CD22, HIB22, PE, 100tests | 60083PE | 100 tests |
Anti-Hu CD22, HIB22, FI, 100tests | 60083FI | 100 tests |
Anti-Hu CD22, HIB22, AZ, 100tests | 60083AZ | 100 tests |
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