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Stemcell 60096PE Anti-Human CD33 Antibody, Clone HIM3-4
Product Overview
The HIM3-4 antibody reacts with CD33 (Siglec-3), an ~67 - 75 kDa type 1 transmembrane sialoadhesion protein of the immunoglobulin superfamily. CD33 is expressed on committed myeloid progenitor cells, monocytes, granulocytes, dendritic cells, mast cells, resident macrophages, and subsets of B cells and activated T and NK cells. CD33 is a major marker used to differentiate myeloid from lymphoid or erythroid leukemias. In peripheral blood it is expressed at high levels on monocytes and at lower levels on granulocytes. CD33 functions as a sialic acid-dependent cell adhesion molecule and mediates protein-glycan and protein-protein interactions between cells. It also has a putative role as an inhibitory receptor during the immune response. HIM3-4 reportedly binds to the extracellular C2 Ig domain of CD33 and does not block subsequent binding of several other anti-CD33 clones, including P67.6, WM53 and WM54. Two isoforms designated CD33M and CD33m have been identified and among these clones only HIM3-4 recognizes both isoforms.
Subtype:一抗
Target Antigen:CD33
Reactive Species:黑猩猩; 人
Conjugation:FITC; PE; 未结合
Host Species:小鼠
Cell Type:粒细胞及其亚型; 髓系细胞
Application:流式细胞术; 免疫细胞化学; 免疫荧光
Area of Interest:免疫学
Clone:HIM3-4
Gene ID:945
Isotype:IgG1, kappa
Related products
Description | Catalog # | Format |
Anti-Hu CD33, HIM3-4, UC, 100µg | 60096 | 100 µg |
Anti-Hu CD33, HIM3-4, PE, 100tests | 60096PE | 100 tests |
Anti-Hu CD33, HIM3-4, PE, 25tests | 60096PE.1 | 25 tests |
Anti-Hu CD33, HIM3-4, FI, 100tests | 60096FI | 100 tests |
Anti-Hu CD33, HIM3-4, FI, 25tests | 60096FI.1 | 25 tests |
Anti-Hu CD32, IV.3, FI, 25 | 60012FI.1 | 0.5 mL |
Anti-Hu CD32, IV.3, FI | 60012FI | 2 mL |
Anti-Hu CD32, IV.3 | 60012 | 0.2 mL |
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