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Stemcell 60113AD Anti-Human CD40 Antibody, Clone 5C3
Product Overview
The 5C3 antibody reacts with CD40, a 45 - 50 kDa type I transmembrane glycoprotein that is a member of the TNFR superfamily. CD40 plays an important role in B cell development and is also involved in the process of B cell selection in germinal centres. It facilitates T cell-B cell interactions for co-stimulation and immune regulation through engagement with CD154 (gp39), the CD40 ligand expressed on T cells. In the presence of IL-4, or other stimuli, CD40 promotes B cell proliferation, induces immunoglobulin- (Ig) isotype class-switching and rescues B cells from surface Ig-induced apoptosis. CD40 is expressed on the surface of B cells, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, endothelial cells, basal epithelial cells, CD34+ hematopoietic progenitor cells, and primary carcinomas. It is expressed at low levels, or not at all, on plasma cells. The 5C3 antibody has been employed for the activation of B cells in in vitro functional assays or for the induction of B cell proliferation.
Subtype:一抗
Target Antigen:CD40
Reactive Species:狒狒; 黑猩猩; 食蟹猴; 人; 猕猴; 松鼠猴
Conjugation:Alexa Fluor 488; APC; FITC; PE; 未结合
Host Species:小鼠
Cell Type:B细胞
Application:流式细胞术; 功能检测; 免疫组化
Area of Interest:免疫学
Clone:5C3
Gene ID:958
Isotype:IgG1, kappa
Related products
Description | Catalog # | Format |
Anti-Hu CD40, 5C3, UC, 500µg | 60113 | 500 µg |
Anti-Hu CD40, 5C3, UC, 50µg | 60113.1 | 50 µg |
Anti-Hu CD40, 5C3, PE, 100tests | 60113PE | 100 tests |
Anti-Hu CD40, 5C3, PE, 25tests | 60113PE.1 | 25 tests |
Anti-Hu CD40, 5C3, FI, 100tests | 60113FI | 100 tests |
Anti-Hu CD40, 5C3, FI, 25tests | 60113FI.1 | 25 tests |
Anti-Hu CD40, 5C3, AZ, 100tests | 60113AZ | 100 tests |
Anti-Hu CD40, 5C3, AZ, 25tests | 60113AZ.1 | 25 tests |
Anti-Hu CD40, 5C3, AD, 100tests | 60113AD | 100 tests |
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