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Stemcell 60114AZ.1 Anti-Human CD41 Antibody, Clone HIP8
Product Overview
The HIP8 antibody reacts with the ~125 kDa GPIIbα subunit of human CD41, a heterodimeric integrin expressed primarily on platelets, megakaryocytes, monocytes and acute megakaryoblastic leukemia cells. The GPIIbα subunit is linked to a smaller ~25 kDa subunit (GPIIbβ) by a single disulfide bond. Three isoforms of CD41 that are generated by alternative splicing have been identified, one of which is expressed only by cancerous cells. CD41 associates non-covalently with CD61 (integrin b3) in a calcium-dependent manner to form the CD41/CD61 (or GPIIb/IIIa) complex, which has been identified as a receptor for several ligands, including fibrinogen, fibronectin, vitronectin and thrombin. Binding to the CD41/CD61 complex involves an RGD tripeptidyl sequence in the ligand, and both ligand occupancy and ligand-mediated receptor clustering are functionally important in the integrin-mediated response. The HIP8 antibody reportedly blocks platelet aggregation and inhibits the activation of platelets by several compounds.
Subtype:一抗
Target Antigen:CD41
Reactive Species:狒狒; 卷尾猴; 黑猩猩; 食蟹猴; 人; 猪; 猕猴
Conjugation:APC; FITC; PE; 未结合
Host Species:小鼠
Cell Type:巨核细胞; 血小板
Application:CyTOF; 流式细胞术; 功能检测; 免疫荧光; 免疫组化; 中和及阻滞
Area of Interest:免疫学
Clone:HIP8
Gene ID:3674
Isotype:IgG1, kappa
Related products
Description | Catalog # | Format |
Anti-Hu CD41, HIP8, UC, 100µg | 60114 | 100 µg |
Anti-Hu CD41, HIP8, PE, 100tests | 60114PE | 100 tests |
Anti-Hu CD41, HIP8, PE, 25tests | 60114PE.1 | 25 tests |
Anti-Hu CD41, HIP8, FI, 100tests | 60114FI | 100 tests |
Anti-Hu CD41, HIP8, FI, 25tests | 60114FI.1 | 25 tests |
Anti-Hu CD41, HIP8, AZ, 100tests | 60114AZ | 100 tests |
Anti-Hu CD41, HIP8, AZ, 25tests | 60114AZ.1 | 25 tests |
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