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Stemcell  60043PE.1  Anti-Human CD51 Antibody, Clone NKI-M9

Product Overview

The NKI-M9 antibody reacts with CD51 (vitronectin receptor α chain, or integrin αV), a type I transmembrane glycoprotein containing two subunits (125 kDa and 24 kDa) which are generated by post-translational cleavage and are linked by a disulfide bond. CD51 associates non-covalently with integrin β1 (CD29), β3 (CD61), β5, β6, or β8 to form heterodimeric cell adhesion receptors for extracellular matrix components such as fibrinogen, collagen, fibronectin, laminin, osteopontin, thrombospondin, vitronectin and von Willebrand factor. For example, association of CD51 and CD61 forms the integrin αv/β3 receptor primarily involved in binding vitronectin. In addition to mediating adhesion and cytoskeletal organization, CD51-containing integrins have roles in signal transduction and thereby modulate processes such as cell proliferation, differentiation and migration. Both ligand binding and ligand-induced receptor clustering are necessary for initiating integrin-mediated responses. CD51 is expressed broadly on many types of cells, including endothelial cells, fibroblasts, monocytes, macrophages, platelets (at relatively low levels) and osteoclasts. It is also found on hepatoma, melanoma and neuroblastoma cells.

Subtype:一抗

Target Antigen:CD51（整合素αV）

Reactive Species:人

Conjugation:生物素; FITC; PE; 未结合

Host Species:小鼠

Cell Type:间充质干细胞和祖细胞

Application:ELISA; 流式细胞术; 功能检测; 免疫沉淀

Area of Interest:干细胞生物学

Clone:NKI-M9

Gene ID:3685

Isotype:IgG2a, kappa

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