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Stemcell  60045FI.1  Anti-Human CD90 Antibody, Clone 5E10

Product Overview

The 5E10 antibody reacts with CD90 (Thy-1), a GPI-linked membrane glycoprotein that is N-glycosylated at two sites, giving rise to 25 - 37 kDa molecules. CD90 has roles in signal transduction, cell adhesion and migration, neurite outgrowth, T cell activation, tumor suppression, and inhibition of the proliferation and differentiation of hematopoietic stem cells. It is a known ligand of β2 and β3 integrins and upregulates synthesis of fibronectin, osteonectin and thrombospondin. CD90 is broadly expressed, being found on human thymocytes, neurons, some glial cells, fibroblasts, activated endothelial cells, some leukemia cell lines and a distinct subset (<1%) of CD3+CD4+ T cells in human peripheral blood. CD90 is also expressed by small subsets of CD34+ cells in fetal liver, umbilical cord blood, bone marrow and mobilized peripheral blood cells. CD90 is considered an important marker for hematopoietic stem and progenitor cells and, in combination with other markers such as CD34, is useful to identify and isolate these cells by FACS.

This antibody clone has been verified for labeling human mesenchymal cells grown in MesenCult™ Proliferation Kit (Human; Catalog #05411) and MesenCult™-XF Medium (Catalog #05420).

Subtype:一抗

Target Antigen:CD90 (Thy-1)

Reactive Species:狒狒; 食蟹猴; 狗; 人; 恒河猴; 猪; 猕猴

Conjugation:APC; 生物素; FITC; PE; PerCP-Cyanine5.5; 未结合

Host Species:小鼠

Cell Type:造血干细胞和祖细胞; 乳腺细胞; 间充质干细胞和祖细胞

Application:CyTOF; ELISA; 流式细胞术; 免疫细胞化学; 免疫荧光; 免疫组化; 免疫沉淀; Western印迹法

Area of Interest:上皮细胞生物学; 干细胞生物学

Clone:5E10

Gene ID:7070

Isotype:IgG1, kappa

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