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Stemcell 60088FI Anti-Human CD183 (CXCR3) Antibody, Clone G025H7
Product Overview
The G025H7 antibody reacts with an extracellular epitope on human CD183 (CXCR3). CD183 is an ~40 kDa seven-pass G protein-coupled transmembrane chemokine receptor expressed predominantly on the surface of IL2-activated (Th1) T cells, as well as on natural killer (NK) cells, dendritic cells, mast cells, alveolar macrophages, eosinophils, and human airway epithelial cells. Binding of chemokines to CD183 induces cellular responses involved in leukocyte migration into inflamed tissue, including Ca2+ mobilization, integrin activation, cytoskeletal rearrangements and chemotaxis, and consequently CD183 plays roles in several inflammatory and autoimmune diseases. Three ligands for CD183 have been identified; Mig (CXCL9), IP-10 (CXCL10) and I-TAC (CXCL11), with the latter exhibiting the highest affinity for CD183 and the most potent induction of the chemotactic response. These chemokines are secreted by a variety of cells upon stimulation by IFN-gamma.
Subtype:一抗
Target Antigen:CD183 (CXCR3)
Reactive Species:食蟹猴; 人; 猕猴
Conjugation:Alexa Fluor 488; APC; FITC; PE; 未结合
Host Species:小鼠
Cell Type:T细胞; T细胞，其他亚型
Application:细胞分离; CyTOF; 流式细胞术; 功能检测
Area of Interest:免疫学
Clone:G025H7
Gene ID:2833
Isotype:IgG1, kappa
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