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Stemcell 60089PE.1 Anti-Human CD184 (CXCR4) Antibody, Clone 12G5
Product Overview
The 12G5 antibody reacts with CD184 (CXCR4 or fusin), an ~45 kDa seven transmembrane G-protein-coupled receptor expressed on the surface of a broad range of cells, including T and B cells, dendritic cells, monocytes, macrophages, granulocytes, platelets, endothelial and epithelial cells, astrocytes and neurons. At least two isoforms of CD184 are generated by alternate mRNA splicing. Ligands for CD184 include the CXC chemokine SDF-1 and ubiquitin. CD184 has functional roles in mediating chemotaxis, B cell lymphopoiesis and myelopoiesis, cardiogenesis, vascularization and neuronal guidance. CD184 acts as a co-receptor for infection by some T cell-tropic isolates of HIV-1 and as an alternative receptor for CD4-independent infection by HIV-2; functions that are blocked by binding of the 12G5 antibody. The antibody also partially inhibits SDF-1-induced chemotaxis and calcium influx. In differentiation studies, CD184 is used along with other markers such as CD117 to monitor the emergence of definitive endoderm.
Subtype:一抗
Target Antigen:CD184 (CXCR4)
Reactive Species:非洲绿猴; 狒狒; 黑猩猩; 食蟹猴; 人; 猕猴; 白颈白眉猴
Conjugation:APC; 生物素; PE; 未结合
Host Species:小鼠
Cell Type:PSC衍生内胚层; 多能干细胞
Application:细胞分离; CyTOF; 流式细胞术; 功能检测; 免疫细胞化学; 免疫荧光; 免疫组化
Area of Interest:免疫学; 干细胞生物学
Clone:12G5
Gene ID:7852
Isotype:IgG2a, kappa
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Description | Catalog # | Format |
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