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Stemcell 60015AZ Anti-Mouse CD3e Antibody, Clone 145-2C11
Product Overview
The 145-2C11 antibody reacts with the ~20 kDa CD3ε subunit of the mouse T cell receptor (TCR)/CD3 complex, which is expressed on the surface of circulating mature T cells and NK-T cells, and variably on thymocytes. A majority of T cell neoplasms also express CD3. The CD3 complex, which is assembled from combinations of CD3γ, δ, ε, η and ζ subunits, associates non-covalently with the TCR and is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR. Activation of T cells by the TCR involves the cytoplasmic tails of the CD3 subunits, which are structurally related type 1 transmembrane proteins and members of the immunoglobulin super family. Mutations in the CD3 subunits have been associated with various immunodeficiency disorders including severed combined immunodeficiency (SCID). The 145-2C11 antibody has been used for in vitro functional (blocking and activation) assays and has been reported to block binding by the clone 17A2 antibody. The 145-2C11 antibody is not recommended for use with formalin-fixed, paraffin-embedded sections.
This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Mouse T Cell Isolation Kit (Catalog #19851) and EasySep™ Mouse CD90.2 Positive Selection Kit II (Catalog #18951).
Subtype:一抗
Target Antigen:CD3e
Reactive Species:小鼠
Conjugation:Alexa Fluor 488; APC; 生物素; FITC; PE; PerCP-Cyanine5.5; 未结合
Host Species:仓鼠
Cell Type:T细胞
Application:细胞分离; ELISA; 流式细胞术; 功能检测; 免疫细胞化学; 免疫荧光; 免疫组化; 免疫沉淀; Western印迹法
Area of Interest:免疫学
Clone:145-2C11
Gene ID:12501
Isotype:IgG1, kappa
Related products
Description | Catalog # | Format |
Anti-Ms CD3e, 145-2C11, PS, 100µg | 60015PS | 100 µg |
Anti-Ms CD3e, 145-2C11, PS, 25µg | 60015PS.1 | 25 µg |
Anti-Ms CD3e, 145-2C11, PE, 50 | 60015PE.1 | 50 µg |
Anti-Ms CD3e, 145-2C11, PE | 60015PE | 200 µg |
Anti-Ms CD3e, 145-2C11, FI, 500µg | 60015FI | 500 µg |
Anti-Ms CD3e, 145-2C11, FI, 50µg | 60015FI.1 | 50 µg |
Anti-Ms CD3e, 145-2C11, BT, 500µg | 60015BT | 500 µg |
Anti-Ms CD3e, 145-2C11, BT, 50µg | 60015BT.1 | 50 µg |
Anti-Ms CD3e, 145-2C11, AZ, 100µg | 60015AZ | 100 µg |
Anti-Ms CD3e, 145-2C11, AZ, 25µg | 60015AZ.1 | 25 µg |
Anti-Ms CD3e, 145-2C11, AD | 60015AD | 100 µg |
Anti-Ms CD3e, 145-2C11 | 60015 | 500 µg |
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