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Stemcell 60009 Anti-Mouse CD25 Antibody, Clone PC61.5
Product Overview
The PC61.5 antibody reacts with murine CD25 (low affinity interleukin‐2 receptor α chain or IL-2Rα), an ~55 kDa type 1 transmembrane glycoprotein expressed on T and B cell progenitors, activated (but not resting) T and B cells, T regulatory (Treg) cells, dendritic cells, and activated monocytes and macrophages. Expression of CD25, together with CD4 and FOXP3, is considered a phenotypic signature for Treg cells. CD25 per se has low affinity for its IL-2 ligand but associates with CD122 (IL-2Rβ) and CD132 (IL-2Rγ) to form the high affinity IL-2R receptor. CD25 is necessary for receptor clustering and induction of signaling pathways involved in the activation and proliferation of lymphocytes. Binding of the PC61.5 antibody inhibits binding of IL-2 to the low and high affinity receptors, which may result in inhibition of IL-2-dependent proliferation. The epitope recognized by PC61.5 is distinct from the IL-2 binding site and from the epitopes recognized by antibodies 7D4 and 3C7.
Subtype:一抗
Target Antigen:CD25
Reactive Species:小鼠
Conjugation:APC; 生物素; PE; PerCP-Cyanine5.5; 未结合
Host Species:大鼠
Cell Type:T细胞; 调节性T细胞
Application:去除; 流式细胞术; 功能检测; 免疫组化; 免疫沉淀; 中和及阻滞
Area of Interest:免疫学
Clone:PC61.5
Gene ID:16184
Isotype:IgG1, lambda
Related products
Description | Catalog # | Format |
Anti-Ms CD25, PC61.5, PS, 100µg | 60009PS | 100 µg |
Anti-Ms CD25, PC61.5, PS, 25µg | 60009PS.1 | 25 µg |
Anti-Ms CD25, PC61.5, PE, 100µg | 60009PE | 100 µg |
Anti-Ms CD25, PC61.5, PE, 25µg | 60009PE.1 | 25 µg |
Anti-Ms CD25, PC61.5, BT, 500µg | 60009BT | 500 µg |
Anti-Ms CD25, PC61.5, BT, 100µg | 60009BT.1 | 100 µg |
Anti-Ms CD25, PC61.5, BT, 25µg | 60009BT.2 | 25 µg |
Anti-Ms CD25, PC61.5, AZ, 100µg | 60009AZ | 100 µg |
Anti-Ms CD25, PC61.5, AZ, 25µg | 60009AZ.1 | 25 µg |
Anti-Ms CD25, PC61.5, 100µg | 60009 | 100 µg |
Anti-Ms CD25, 3C7, PE, 25 | 60010PE.1 | 25 µg |
Anti-Ms CD25, 3C7, PE | 60010PE | 100 µg |
Anti-Ms CD25, 3C7, FI, 50 | 60010FI.1 | 50 µg |
Anti-Ms CD25, 3C7, FI | 60010FI | 500 µg |
Anti-Ms CD25, 3C7 | 60010 | 500 µg |
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