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Stemcell 60019AD.1 Anti-Mouse CD45R Antibody, Clone RA3-6B2
Product Overview
The RA3-6B2 antibody reacts with an epitope on the extracellular domain of the exon A‐restricted isoform of mouse CD45. CD45 is a member of the protein tyrosine phosphatase family and functions in a number of immunoregulatory processes, including cell activation, growth, differentiation, and oncogenic transformation. The large cytoplasmic portion of CD45 contains two tyrosine phosphatase domains (one which is enzymatically active) that are involved in modulating the function of Src kinases such as Lck and Fyn. Several isoforms of CD45 have been identified, the expression of which differs according to cell type and functional status. Alternative splicing of three exons encoding the extracellular RA, RB and RC polypeptide sequences gives rise to up to 8 isoforms with molecular masses in the range of 200 - 220 kDa. The exon A‐restricted isoform of mouse CD45, termed CD45R, contains the RA, RB, and RC regions and is the largest of the isoforms. CD45R is expressed by the B cell lineage from early pro‐B to mature B cells, with its expression downregulated during differentiation to plasma cells. CD45R is also expressed on subsets of T, NK, dendritic, and lymphokine-activated killer (LAK) cells. This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Mouse B Cell Enrichment Kit (Catalog #19754) and EasySep™ Mouse B Cell Isolation Kit (Catalog #19854).
Subtype:一抗
Target Antigen:CD45R (B220)
Reactive Species:猫; 人; 小鼠
Conjugation:Alexa Fluor 488; APC; 生物素; FITC; PE; PerCP-Cyanine5.5; 未结合
Host Species:大鼠
Cell Type:B细胞; 淋巴细胞
Application:CyTOF; 流式细胞术; 功能检测; 免疫细胞化学; 免疫荧光; 免疫组化; 免疫沉淀; Western印迹法
Area of Interest:免疫学; 移植研究
Clone:RA3-6B2
Gene ID:19264/5788
Isotype:IgG2a, kappa
Related products
Description | Catalog # | Format |
Anti-Ms CD45R, RA3-6B2, UC, 50µg | 60019.1 | 50 µg |
Anti-Ms CD45R, RA3-6B2, PS, 100µg | 60019PS | 100 µg |
Anti-Ms CD45R, RA3-6B2, PS, 25µg | 60019PS.1 | 25 µg |
Anti-Ms CD45R, RA3-6B2, PE, 50 | 60019PE.1 | 50 µg |
Anti-Ms CD45R, RA3-6B2, PE | 60019PE | 200 µg |
Anti-Ms CD45R, RA3-6B2, FI, 500µg | 60019FI | 500 µg |
Anti-Ms CD45R, RA3-6B2, FI, 50µg | 60019FI.1 | 50 µg |
Anti-Ms CD45R, RA3-6B2, BT, 500µg | 60019BT | 500 µg |
Anti-Ms CD45R, RA3-6B2, BT, 50µg | 60019BT.1 | 50 µg |
Anti-Ms CD45R, RA3-6B2, AZ, 100µg | 60019AZ | 100 µg |
Anti-Ms CD45R, RA3-6B2, AZ, 25µg | 60019AZ.1 | 25 µg |
Anti-Ms CD45R, RA3-6B2, AD, 25µg | 60019AD.1 | 25 µg |
Anti-Ms CD45R, RA3-6B2, AD | 60019AD | 100 µg |
Anti-Ms CD45R, RA3-6B2 | 60019 | 500 µg |
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