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Stemcell 60037AZ.1 Anti-Mouse CD49f Antibody, Clone GoH3
Product Overview
The GoH3 antibody reacts with CD49f (integrin α6), an ~150 kDa transmembrane glycoprotein that associates non-covalently with CD29 (integrin β1) or CD104 (integrin β4) to form the heterodimeric receptors VLA-6 and α6β4, which bind the extracellular matrix protein laminin. CD49f is a disulfide-linked dimer comprising an ~120 kDa heavy chain and an ~30 kDa membrane-bound light chain. Splice variants exist, which affect the cytoplasmic domain of the protein. CD49f is expressed on the surface of T cells, monocytes, platelets, placental trophoblasts, epithelial and endothelial cells. It is involved in cell adhesion and regulating signaling pathways involved in a variety of processes, including the activation and proliferation of T cells, and the differentiation and maintenance of pluripotency of stem cells. CD49f is considered the most important marker for selecting mouse mammary stem and progenitor cells. The GoH3 antibody reacts with an extracellular epitope on CD49f and reportedly blocks integrin α6 function in vivo and binding of integrin α6 to laminin in vitro.
Subtype:一抗
Target Antigen:CD49f（整合素α6）
Reactive Species:狒狒; 卷尾猴; 食蟹猴; 猕猴; 猫; 黑猩猩; 牛; 狗; 马; 人; 小鼠; 猪; 兔; 羊
Conjugation:Alexa Fluor 488; APC; 生物素; FITC; PE; 未结合
Host Species:大鼠
Cell Type:乳腺细胞
Application:流式细胞术; 功能检测; 免疫细胞化学; 免疫荧光; 免疫组化; 免疫沉淀
Area of Interest:上皮细胞生物学; 免疫学
Clone:GoH3
Gene ID:16403/3655
Isotype:IgG2a, kappa
Related products
Description | Catalog # | Format |
Anti-Ms CD49f, GoH3, PE, 25 | 60037PE.1 | 25 tests |
Anti-Ms CD49f, GoH3, PE | 60037PE | 100 tests |
Anti-Ms CD49f, GoH3, FI, 100tests | 60037FI | 100 tests |
Anti-Ms CD49f, GoH3, FI, 25tests | 60037FI.1 | 25 tests |
Anti-Ms CD49f, GoH3, BT, 100µg | 60037BT | 100 µg |
Anti-Ms CD49f, GoH3, BT, 25µg | 60037BT.1 | 25 µg |
Anti-Ms CD49f, GoH3, AZ, 100tests | 60037AZ | 100 tests |
Anti-Ms CD49f, GoH3, AZ, 25tests | 60037AZ.1 | 25 tests |
Anti-Ms CD49f, GoH3, AD, 25 | 60037AD.1 | 25 tests |
Anti-Ms CD49f, GoH3, AD | 60037AD | 100 tests |
Anti-Ms CD49f, GoH3 | 60037 | 100 µg |
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