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Stemcell 60025FI.1 Anti-Mouse CD117 Antibody, Clone 2B8
Product Overview
The 2B8 antibody reacts with CD117 (c-Kit), an ~145 kDa type 1 transmembrane receptor for c-Kit ligand (stem cell factor/steel factor) that is broadly expressed on hematopoietic stem cells in bone marrow, including pluripotent and erythroid progenitor cells and B and T lymphocyte precursors, as well as on mast cells. CD117 belongs to the tyrosine kinase receptor family and possesses five immunoglobulin-like C2-type domains and a cytoplasmic protein kinase domain. Binding of c-Kit ligand to CD117 induces dimerization and autophosphorylation, which activates several intracellular signaling pathways critical for the proliferation and differentiation of hematopoietic stem cells. Signaling by CD117 is modulated by phosphatases and by rapid endocytosis and degradation of the receptor. The 2B8 antibody does not block binding of c-Kit ligand. Mutations in CD117 are associated with various types of tumors and the piebald trait, an autosomal dominant abnormality of pigmentation.
This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Mouse Hematopoietic Progenitor Cell Enrichment Kit (Catalog #19756).
Subtype:一抗
Target Antigen:CD117 (c-Kit)
Reactive Species:小鼠
Conjugation:Alexa Fluor 488; APC; 生物素; FITC; PE; 未结合
Host Species:大鼠
Cell Type:造血干细胞和祖细胞
Application:细胞分离; 流式细胞术; 免疫细胞化学; 免疫荧光; 免疫组化; 免疫沉淀
Area of Interest:干细胞生物学
Clone:2B8
Gene ID:16590
Isotype:IgG2b, kappa
Related products
Description | Catalog # | Format |
Anti-Ms CD117, ACK2, PE, 50 | 60034PE.1 | 50 µg |
Anti-Ms CD117, ACK2, PE | 60034PE | 200 µg |
Anti-Ms CD117, ACK2, FI, 50µg | 60034FI | 50 µg |
Anti-Ms CD117, ACK2, AZ, 100µg | 60034AZ | 100 µg |
Anti-Ms CD117, ACK2, AZ, 25µg | 60034AZ.1 | 25 µg |
Anti-Ms CD117, ACK2, AD, 100µg | 60034AD | 100 µg |
Anti-Ms CD117, ACK2, AD, 25µg | 60034AD.1 | 25 µg |
Anti-Ms CD117, ACK2, 50µg | 60034.1 | 50 µg |
Anti-Ms CD117, ACK2 | 60034 | 500 µg |
Anti-Ms CD117, 2B8, PE, 50 | 60025PE.1 | 50 µg |
Anti-Ms CD117, 2B8, PE | 60025PE | 200 µg |
Anti-Ms CD117, 2B8, FI, 500µg | 60025FI | 500 µg |
Anti-Ms CD117, 2B8, FI, 50µg | 60025FI.1 | 50 µg |
Anti-Ms CD117, 2B8, BT, 500µg | 60025BT | 500 µg |
Anti-Ms CD117, 2B8, BT, 50µg | 60025BT.1 | 50 µg |
Anti-Ms CD117, 2B8, AZ, 100µg | 60025AZ | 100 µg |
Anti-Ms CD117, 2B8, AZ, 25µg | 60025AZ.1 | 25 µg |
Anti-Ms CD117, 2B8, AD, 25 | 60025AD.1 | 25 µg |
Anti-Ms CD117, 2B8, AD | 60025AD | 100 µg |
Anti-Ms CD117, 2B8 | 60025 | 500 µg |
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