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Stemcell  60055  Anti-Sox-2 Antibody

Product Overview

The Poly6519 polyclonal antibody reacts with human Sox-2 (SRY-box 2), an ~34 kDa nuclear transcription factor containing a high motility group DNA-binding domain which functions to bind and open the DNA helix, thus facilitating the actions of other transcription factors. Sox-2 is known to associate with Oct-4. Expression of Sox-2 occurs throughout the brain, including the developing hypothalamus and anterior pituitary, and the eye. The protein regulates several genes that control embryogenesis and differentiation. Its expression has been observed as early as the preimplantation stage but becomes restricted to the neuroepithelium and, later, to neural stem and progenitor cells. Sox-2 is required for maintaining the self-renewal and pluripotency capabilities of embryonic stem (ES) cells. In concert with other factors, Sox-2 has been used to reprogram differentiated cells into induced pluripotent stem (iPS) cells. Certain mutations in the Sox-2 gene are associated with optic nerve hypoplasia and anophthalmia, a severe developmental defect of the eyes.

This antibody clone has been verified for labeling human ES and iPS cells grown in mTeSR™1 (Catalog #05850/05857/05870/05875) and TeSR™2 (Catalog #05860/05880).

Subtype:一抗

Target Antigen:Sox-2

Reactive Species:人; 小鼠

Conjugation:未结合

Host Species:兔

Cell Type:PSC衍生神经细胞; 神经干细胞和祖细胞; 多能干细胞

Application:流式细胞术; 免疫细胞化学; 免疫荧光; Western印迹法

Area of Interest:神经科学; 干细胞生物学

Clone:Not applicable (Poly6519)

Gene ID:6657

Isotype:Not applicable

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