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CFSE, 10mg 75003 10 mg
Product Overview
CFSE (carboxyfluorescein diacetate succinimidyl ester or CFDA-SE) is a stable, non-fluorescent, cell-permeable derivative of fluorescein containing two acetate groups and a succinimidyl ester functional group. Upon diffusion into the cell, intracellular esterases cleave the acetate groups to generate a highly fluorescent (green) dye that is impermeant to the cell membrane, and covalent binding of the succinimidyl ester to free amine groups forms a stable intracellular label. At appropriate concentrations CFSE is not toxic to cells and as the cells divide, CFSE is partitioned approximately equally between the progeny so that cell division can be followed as a successive halving of the fluorescence intensity through multiple generational divisions. CFSE is most widely used for cell proliferation and motility assays, and in vivo cell tracking experiments (ex vivo labeling of cells for adoptive transfer). CFSE-labeled cells can be detected with any instrument/filter set compatible with fluorescein detection.
Application:流式细胞术; 免疫细胞化学; 免疫荧光
Area of Interest:免疫学; 神经科学; 干细胞生物学
Chemical Formula:C₂₉H₁₉NO₁₁
Molecular Weight:557.5 g/mol
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