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Stemcell 73074 Dabrafenib
Product Overview
Dabrafenib is a reversible, selective, and ATP-competitive inhibitor of B-RAF with higher potency towards V600E mutant B-RAF over wild-type B-RAF or C-RAF, with IC₅₀ values of 0.8, 3.2 and 5 nM, respectively (Laquerre et al.; Menzies et al.).
CANCER RESEARCH
· Decreases ERK phosphorylation and inhibits cell proliferation in cells expressing the B-RAF mutation V600E. Prevents tumor growth in mouse xenograft models of B-RAF(V600E) human melanoma and colon cancer (Rheault et al.).
DISEASE MODELING
· Alleviates acetaminophen-induced liver injury through distinct nanomolar inhibition of receptor-interacting protein (RIP3) in mice (Li et al.).
CAS Number:1195765-45-7
Alternative Names:GSK 2118436, Dabarefenib, Tafinlar™
Chemical Formula:C₂₃H₂₀F₃N₅O₂S₂
Molecular Weight:519.6 g/mol
Purity:≥ 98%
Pathway:MEK/ERK
Target:B-RAF
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Dabrafenib, 50 mg | 73074 | 50 mg |
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