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Stemcell 72082 DAPT
Product Overview
DAPT is an inhibitor of the γ-secretase complex. Notch is a key target of γ-secretase, therefore DAPT indirectly inhibits the Notch pathway. Other targets of γ-secretase that would be influenced by DAPT include amyloid precursor protein, E-cadherin, and ErbB4. (Dovey et al.).
MAINTENANCE AND SELF-RENEWAL
· Reduces colony-forming efficiency of mouse neural stem cells (Androutsellis-Theotokis et al.).
· Enhances radiation-induced cell death of glioma stem cells (Wang et al.).
DIFFERENTIATION
· Promotes differentiation of nociceptors from human pluripotent stem cells, in combination with several other small molecules (Chambers et al.).
· Promotes differentiation of neurons from human and mouse embryonic stem (ES) cells (Crawford and Roelink, Elkabetz et al.).
· Promotes differentiation of retinal pigment epithelium from mouse ES cells (Osakada et al.).
· Promotes differentiation of pancreatic cells from human pluripotent stem cells (D'Amour et al.).
CANCER RESEARCH
· Reduces mammosphere-forming efficiency of breast cancer cell lines and ductal carcinoma in situ cells (Farnie et al., Harrison et al.).
CAS Number:208255-80-5
Alternative Names:GSI-IX; LY-374973
Chemical Formula:C₂₃H₂₆F₂N₂O₄
Molecular Weight:432.5 g/mol
Purity:≥ 95%
Pathway:Notch
Target:γ-Secretase
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