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Stemcell 72102 Dorsomorphin
Product Overview
Dorsomorphin inhibits the BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. It is also a potent inhibitor of AMPK (Ki = 109 nM) but does not significantly inhibit structurally related kinases such as ZAPK, SYK, PKCθ, PKA or JAK3. (Bain et al., Yu et al.)
DIFFERENTIATION
· Promotes differentiation of neural progenitor cells from human pluripotent stem cells (Morizane et al., Zhou et al.).
· Promotes differentiation of cardiomyocytes from mouse and human pluripotent stem cells (Hao et al., Kattman et al.).
· Promotes differentiation of adipocytes and suppresses osteogenic differentiation of osteoblasts from human mesenchymal cells (Kim et al.).
CAS Number:866405-64-3
Alternative Names:Compound C
Chemical Formula:C₂₄H₂₅N₅O
Molecular Weight:399.5 g/mol
Purity:≥ 98%
Pathway:AMPK; BMP
Target:ALK2; ALK3; ALK6; AMPK
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