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Stemcell 72452 Garcinol
Product Overview
Garcinol is an inhibitor of histone acetyltransferases (HATs) p300 and pCAF (IC₅₀ = 7 and 5 μM, respectively) (Balasubramanyam et al.). It also inhibits the HAT GCN5 in Cryptococcus neoformans, inducing temperature sensitivity and impairing growth (O’Meara et al.).
MAINTENANCE AND SELF-RENEWAL
· Promotes ex vivo expansion of human hematopoietic stem cells (Nishino et al.).
DIFFERENTIATION
· Promotes neurogenesis in rat cortical progenitor cells (Weng et al.).
CANCER
· Induces apoptosis in several types of cancer cells and has anti-inflammatory actions (Koeberle et al.; Prasad et al.).
CAS Number:78824-30-3
Alternative Names:Camboginol
Chemical Formula:C₃₈H₅₀O₆
Molecular Weight:602.8 g/mol
Purity:≥ 95%
Pathway:Epigenetic
Target:HAT
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