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Stemcell 73162 Gefitinib
Product Overview
Gefitinib is a selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase that binds competitively in the ATP binding pocket with IC₅₀ values of 23 and 80 nM for A431 vulval squamous carcinoma cells and KB cells, respectively (Barker et al.).
CANCER RESEARCH
· Blocks proliferation in vitro and in mouse xenograft models, of multiple cancer cell types including colon, ovarian, and breast cancer cell lines (Ciardiello et al.).
· Induces apoptosis in the HaCaT human keratinocyte cell line via a c-Jun N-terminal kinase (JNK) activation, an EGFR-independent mechanism (Lu et al.).
CAS Number:184475-35-2
Alternative Names:Iressa™, ZD1839, Gefonib
Chemical Formula:C₂₂H₂₄ClFN₄O₃
Molecular Weight:446.9 g/mol
Purity:≥ 98%
Pathway:酪氨酸激酶
Target:EGFR
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