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Stemcell 72474 GW2580
Product Overview
GW2580 is a selective inhibitor of cFMS kinase (IC₅₀ = 0.03 μM) (Conway et al., 2008), blocking its ability to autophosphorylate colony-stimulating factor (CSF-1, or M-CSF), which promotes the survival, proliferation, and differentiation of macrophages.
DIFFERENTIATION
· Demonstrates the importance of CSF-1 in promoting myeloid lineage bias in mouse hematopoietic stem cells (Mossadegh-Keller et al.).
· Demonstrates the importance of CSF-1 in expansion of mouse and human macrophage colonies and monocytes (He et al.; Clanchy et al.; Conway et al., 2008; Conway et al., 2005).
· Inhibits bone degradation in cultures of human osteoclasts, rat calvaria, and rat fetal long bone (Conway et al., 2005), and in mouse models of arthritis (Conway et al., 2008).
CAS Number:870483-87-7
Alternative Names:Not applicable
Chemical Formula:C₂₀H₂₂N₄O₃
Molecular Weight:366.4 g/mol
Purity:≥ 98%
Pathway:CSF-1
Target:cFMS
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