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Stemcell 72462 Gö6983
Product Overview
Gö6983 inhibits several isoforms of protein kinase C (PKC; IC₅₀ = 7, 7, 6, 10, 60, and 20,000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ, and PKCμ, respectively) (Gschwendt et al.).
REPROGRAMMING
· Enhances reprogramming of mouse embryonic fibroblasts to induced pluripotent stem cells (Dutta et al.).
· Direct lineage reprogramming of fibroblasts to mature neurons, in combination with CHIR99021, RepSox, Forskolin, SP600125, Valproic Acid, and Y-27632 (Hu et al.).
MAINTENANCE AND SELF-RENEWAL
· Inhibits differentiation and maintains pluripotency in mouse embryonic stem cells (Dutta et al.).
· Enhances human ground state pluripotent stem cell viability and growth (Gafni et al.).
· Inhibits proliferation of human primary fetal bone cells (Krattinger et al.).
· Inhibits the formation of protoplatelets from megakaryocytes derived from adult mouse bone marrow (Williams et al.).
CAS Number:133053-19-7
Alternative Names:Gö 6983
Chemical Formula:C₂₆H₂₆N₄O₃
Molecular Weight:442.5 g/mol
Purity:≥ 98%
Pathway:PKC
Target:PKC
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