StemRD ACT-100 Activin A, human

产品编号ACT-100 | StemRD

Activin A, 人

产品描述

a member of the TGF-beta superfamily. It is a 26 kDa disulfide-linked homodimer of two beta-A chains, each containing 116 amino acid residues. Activin A is widely used in stem cell research, such as in differentiation of embryonic stem cells to definitive endoderm. The biological activities of Activin A can be neutralized by diffusible TGF-beta antagonists, Follistatin (available from StemRD). StemRD's Activin A is made in human 293 cells in xeno-free medium, which renders human-specific post-translational modifications. We purified this product through a series of chromatography including HPLC to >95% pure. Activity is determined by using a SMAD reporter assay to be EC50 ~1 ng/mL. Data shown are typical HPLC profile and SDS-PAGE of StemRD's Activin A.
公司简介

StemRD Inc. is located in the San Francisco Bay Area, we specialize in producing premier research reagents for the stem cell research community. Our mission is to empower stem cell R&D through innovative technologies. Our proprietary technology in protein expression and purification has allowed efficient production of several important factors, such as WNT, Hedgehog, TGF-ß family members and Differentiation Kits, that are difficult to obtain by conventional methods.

StemRD 是美国一家聚焦于尖端干细胞研究的公司，拥有蛋白表达和纯化方面的专利技术。拥有被美国FDA认证的可用于GMP生产治疗型多肽的设施。StemRD的实验室拥有包括组织培养、细胞处理、超离心、超过滤、FPLC、HPLC和LC/MS等一系列先进设备。其中干细胞研究用生长/分化因子、小分子化合物均包括目前研究较多的WNT/β-catenin、TGF-β、Hedgehog、Notch等信号通路等。