Anti-β-Amyloid, 17-24

￥ 12586.00

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Biolegend(Covance) 800709 Anti-β-Amyloid, 17-24 Antibody

产品编号 800709 | Biolegend(Covance)

产品描述

Clone:	4G8 (See other available formats)
Isotype:	Mouse IgG2b
Reactivity:	Human, Mouse
Preparation:	Ascites
Concentration:	The concentration is not quantified as this product is sold as undiluted crude mouse ascites fluid. The concentration might vary from lot-to-lot and an estimated concentration would be 1-3 mg/ml.
Storage & Handling:	Store at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers.
Application:	ELISA, WB, IHC, IP
Recommended Usage:	Each lot of this antibody is quality control tested by ELISA assay.The optimal working dilution should be determined for each specific assay condition. • WB: 1:100 - 1:1,000*• IHC: 1:500 - 1:1,000• IP: 1:250 - 1:500Tissue: Formalin-fixed human and animal paraffin-embedded brain sections, frozen tissue sectionsPre-treatment: Formic acid (70%) for 10-30 minutes at room temperature
ApplicationNotes:	This antibody is effective in immunoblotting (WB), immunohistochemistry (IHC), immunoprecipitation (IP) immunoaffinity purifications, and ELISA. *Expected MW: APP = 100 kD, Beta Amyloid = 4 kDThis antibody is reactive to amino acid residues 17-24 of beta amyloid. The epitope lies within amino acids 18-22 of beta Amyloid (VFFAE). Beta amyloid forms are deposited in the CNS of patients with Alzheimer’s disease and Down’s syndrome. This antibody reacts to the abnormally processed isoforms, as well as precursor forms.
ApplicationReferences:	1. Thakker DR, et al. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci USA Feb 25, 2009.2. Kimura N, et al. Age-related changes of intracellular Abeta in cynomolgus monkey brains. Neuropath Appl Neurobiol 31(2):170-80, 2005.3. Klyubin I, et al. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med 11(5):556-61, 2005.4. Iijima K, et al. Dissecting pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease. PNAS 101(17):6623-6628, 2004.5. Li M, et al. Macrophage colony stimulatory factor and interferon-gamma trigger distinct mechanisms for augmentation of beta-amyloid-induced microgliamediated neurotoxicity. J Neurochem 91:623-33, 2004.6. Poduloso JF, et al. Design and chemical synthesis of a magnetic resonance contrast agent with enhanced in vitro binding, high blood-brain barrier permeability, and in vivo targeting to Alzheimer's disease amyloid plaques. Biochem 43:6064-6075, 2004.7. Abramowksi D, et al. J Neurosci. 32:1273. (WB, IP) PubMed 8. Lessard C, et al. 2015. PLOS ONE. 10: 0144758. PubMed9. Choi S, et al. 2015. PLOS ONE. 10: 0143854. PubMed10. Whitehouse I, et al. 2016. PLOS ONE. 11: 0159119. PubMed
	Publication Library
RRID:	AB_2565325 (BioLegend Cat. No. 800709)AB_2565326 (BioLegend Cat. No. 800710)AB_2565324 (BioLegend Cat. No. 800711)

公司简介

Covance主要业务是研发和生产各种抗体，涉及领域包括：神经生物学、免疫病理学、细胞生物学、表位抗体和免疫组化等方面的科研试剂。特色产品是免疫组化的体外诊断试剂。美国 BioLegend 公司于圣地亚哥时间2014年8月29日收购了位于马萨诸塞州戴德姆的科文斯（Covance）旗下的科文斯抗体服务公司（Covance Antibody Services Inc.）。科文斯抗体服务公司主要业务是研发和生产各种抗体，涉及领域包括:神经生物学、免疫病理学、细胞生物学、表位抗体和免疫组化等方面的科研试剂。这些用于免疫组化的体外诊断试剂（IVD）对于 BioLegend 公司目前的科研试剂产品线是一个很好的补充和扩展。科文斯抗体的客户将享有与 BioLegend 当前客户同样的优质服务和高性价比的产品。

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市场价

￥12586.00

价格

￥12586.00

品牌

Biolegend(Covance)

型号

800709