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Research Diets D10012M AIN Diets-93M- D10012M
产品编号 D10012M |Research Diets
AIN Diets
产品描述
AIN Diets
History
In the early days of purified diet use, many research nutrition groups developed; each using their own favorite purified diet and usually using making them in house. For example, Vitamin A researchers developed separate and very distinct purified diet formulas from those studying Vitamin D or selenium or Vitamin E. Because of these differences, it became quite difficult to compare observations across these nutrient study disciplines, from lab group to lab group. Despite these differences, the formulas were generally well reported, allowing one group to know exactly what another group had fed their animals.
In the early 1970's, the American Institute of Nutrition (AIN) recognized that research nutritionists were traveling down these many separate tracks and also that other non-nutrition biologists were returning to the fold and using purified ingredient diets to study all aspects of health and disease. The AIN formed a committee and designed the AIN-76 rodent diet to 'guide' research and suggested that a simple purified ingredient diet be adopted for use as a 'standard' purified diet by all biologists. The AIN-76A rodent diet formula was the result.
In the AIN-76A rodent diet, the protein requirement is met by the milk protein casein, along with added methionine (to meet sulfur-containing amino acid requirements). Carbohydrates in this case are supplied by corn starch and sucrose, corn oil provides the fat and cellulose supplies the fiber. Vitamin and mineral mixes specific to rodents are added to ensure adequacy. Each nutrient is supplied by a separate, purified ingredient. (It is true that casein, for example contains trace levels of certain vitamins and will contain small amounts of some minerals. In general this only becomes of importance when the goal of the experiment is to induce a deficiency state in one of those vitamins or minerals. In those cases, one can use alcohol-extracted casein [to remove the trace amounts of fat and fat-soluble vitamins] or individual amino acids [the literal links in the protein chain] to lower the background levels of these nutrients).
In 1993 because of numerous nutritional and technical problems encountered with the diet during this period, AIN-76A was revised. Two new formulations were derived: AIN-93G for growth, pregnancy and lactation, and AIN-93M for adult maintenance. Some major differences in the new formulation of AIN-93G compared with AIN-76A are as follows: 7 g soybean oil/100 g diet was substituted for 5 g corn oil/100 g diet to increase the amount of linolenic acid; cornstarch was substituted for sucrose; the amount of phosphorus was reduced to help eliminate the problem of kidney calcification in female rats; L-cystine was substituted for DL-methionine as the amino acid supplement for casein, known to be deficient in the sulfur amino acids; manganese concentration was lowered to one-fifth the amount in the old diet; the amounts of vitamin E, vitamin K and vitamin B-12 were increased; and molybdenum, silicon, fluoride, nickel, boron, lithium and vanadium were added to the mineral mix. For the AIN-93M maintenance diet, the amount of fat was lowered to 40 g/kg diet from 70 g/kg diet, and the amount of casein to 140 g/kg from 200 g/kg in the AIN-93G diet. Because of a better balance of essential nutrients, the AIN-93 diets may prove to be a better choice than AIN-76A for long-term as well as short-term studies with laboratory rodents.(1)
References
1. Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993 Nov;123(11):1939-51.
产品详情
Stock Diets
- A number of OpenSource diet formulations have been widely published and have become the standards for many diet-induced disease models. These diets are kept in stock and ready for next day shipment. Our stock diets provide a clean, open formula background in which to make modifications. See our custom diets page for more information on custom formulations.
- The following is a list of our stock purified diets:
- All our stock diets can be irradiated. To order irradiated diets add the letter "i" to the end of the diet number. For example D12492i.
- These are just a few of the over 20,000 original diet formulas available to you. Contact one of ournutrition scientists for assistance in finding the formula for you specific study needs.
- Don’t be misled by diet manufacturers who claim to offer the same OpenSource diet formulas as Research Diets, Inc. Though it is true that all our formulas are open, there may be differences in the sources of ingredients or the vitamin and mineral mixes used to produce the diet. There is only one sure way to repeat research based on the "Original" OpenSource Diet formula—go to the source of that formula. There is only one place to get OpenSource Diets and that’s at Research Diets, Inc.
Formulation | Description | In-Stock | IrradiatedIn-Stock | |
DIO (LFD) 10 kcal% fat 35% Sucrose | Yes | Yes | ||
DIO (LFD) 10 kcal% fat D12492 Match 17% Sucrose | Yes | |||
DIO (HFD) 45 kcal% fat | Yes | Yes | ||
DIO (VHFD) 60 kcal% fat | Yes | Yes | ||
AIN-76A | Yes | |||
AIN-93G | Yes | |||
AIN-93M | Yes | |||
Purified match to C11024 Condensed Milk Diet | ||||
Low-fat control to D12266B | ||||
RD Western Diet | Yes | |||
58 kcal% fat w/corn starch | ||||
Control: 11 kcal% fat w/corn starch | ||||
58 kcal% fat w/sucrose | Yes | Yes | ||
Control: 11 kcal% fat w/sucrose | ||||
40 kcal% fat (mostly cocoa butter) and 1.25% cholesterol | Yes |
A Word of Caution
公司简介
美国research diets公司是一家专业生产实验室动物饲料的大型公司，包括脂肪热能的颗粒饲料及各种维生素缺乏饲料的专业供应商，Research Diets是生产动物实验用高脂肪饲料的先驱，可配制高达 60 kcal% 的高脂肪饲料，成份內含各式脂肪及碳水化合物，Research Diets长期陪伴实验室科研人员，以配制研究需要的饲料配方，可用于诱发肥胖病及糖尿病的特殊饲料如D12450B、D12451及 D12492, Research Diets拥有配方饲料种类超过15000种，常规高端饲料10多种如AIN-76A Western饲料等’
Uante,您的科研物资战略合作伙伴！
重庆市寰宇安泰生物科技有限公司
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