The “Original” High-Fat Diets forDiet Induced Obesity
Research Diets, Inc. formulated the “original” high-fat diet for diet induced obesity (DIO) studies in 1996. Today, our high-fat diets are the research standard for DIO mice and rats worldwide.
DIO Low-Fat Control Diets
Matched, Purified Ingredient Diet We recommend that you use a matched, puri_ed ingredient diet and not a grain-based 'chow' diet. _ere are many, many di_erences between puri_ed diets and chow diets and these variables make it di_cult to interpret your data from a study in which one group was fed a puri_ed ingredient high-fat and the other a low-fat chow diet. Di_erences between your groups could be due to the level of fat, but could also be due to di_erences in _ber type and level, source of carbohydrate, and the presence or absence of plant
Low-Fat Control Formulas
There are many options for low-fat control diets. Here are a few examples:
D12450B
Contains 35% sucrose by energy, unlike D12451 and D12492. Sucrose is made up of glucose and fructose and it has been shown that diets very high in sucrose or fructose (~60-70% by energy) can induce hypertriglyceridemia, insulin resistance and fatty liver.
Match Sucrose Calories
Keep the amount of sucrose (as a percent of calories) constant across low and high-fat diets. D12450H matches the sucrose calories in D12451. D12450J matches the sucrose calories in D12492. THese diets are formulated in such a way that when animals in the low and high-fat groups consume the same number of calories, they
Replace Sucrose with Corn Starch
D12450K contains no sucrose but only corn starch and maltodextrin as the sources of carbohydrate. Maltodextrin is a partially hydrolyzed form of corn starch that allows us to produce a quality pellet in a high corn starch diet. there are more possible low-fat diet formulas. Please contact one of our scientists and we can help you decide if one of the above diets or perhaps a di_erent, custom diet is better for your research.
Formulation | Description | In-Stock | IrradiatedIn-Stock | |
DIO (LFD) 10 kcal% fat 35% Sucrose | Yes | Yes | ||
DIO (LFD) 10 kcal% fat D12492 Match 17% Sucrose | Yes | |||
DIO (HFD) 45 kcal% fat | Yes | Yes | ||
DIO (VHFD) 60 kcal% fat | Yes | Yes | ||
AIN-76A | Yes | |||
AIN-93G | Yes | |||
AIN-93M | Yes | |||
Purified match to C11024 Condensed Milk Diet | ||||
Low-fat control to D12266B | ||||
RD Western Diet | Yes | |||
58 kcal% fat w/corn starch | ||||
Control: 11 kcal% fat w/corn starch | ||||
58 kcal% fat w/sucrose | Yes | Yes | ||
Control: 11 kcal% fat w/sucrose | ||||
40 kcal% fat (mostly cocoa butter) and 1.25% cholesterol | Yes |
美国research diets公司是一家专业生产实验室动物饲料的大型公司,包括脂肪热能的颗粒饲料及各种维生素缺乏饲料的专业供应商,Research Diets是生产动物实验用高脂肪饲料的先驱,可配制高达 60 kcal% 的高脂肪饲料,成份內含各式脂肪及碳水化合物,Research Diets长期陪伴实验室科研人员,以配制研究需要的饲料配方,可用于诱发肥胖病及糖尿病的特殊饲料如D12450B、D12451及 D12492, Research Diets拥有配方饲料种类超过15000种,常规高端饲料10多种如AIN-76A Western饲料等’
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