InvivoGen  fc-hdec1a  Fc-hDectin-1a

Fc-hDectin-1a is a soluble human Dectin-1 receptor constructed by fusing the C-terminal extracellular domain of human Dectin-1a (aa 67-247) to the C-terminus of an engineered human IgG1 Fc domain with a 10 amino acid linker.

Fc-hDectin-1a has an apparent molecular weight of ~55 kDa on SDS-PAGE.

Fc-hDectin-1a is expressed in CHO cells and purified by protein G affinity chromatography.

产品描述

Soluble PRR Receptors

InvivoGen provides soluble forms of the pattern recognition receptors, Dectin-1 and TLR5, that consist of the extracellular domain (ECD) of each receptor fused to an IgG1 Fc domain, engineered to reduce ADCC and enhance half-life.

Dectin-1, which is a type-II transmembrane receptor, is fused to the C-terminus of the Fc domain while TLR5, which is a type-1 transmembrane receptor is fused to the N-terminus of the Fc domain. The Fc fusion proteins are expressed in CHO cells and purified by protein G affinity chromatography.

The soluble Dectin-1 and TLR5 receptors can be used for receptor binding assays or neutralization studies.

其他产品线

1-Cell Culture and Transfection Reagents:

Powerful reagents to prevent microbial contamination in cell culture, plus a wide variety of selection antibiotics and reporter (secreted embryonic alkaline phosphatase (SEAP) or Lucia luciferase) detection reagents, and a transfection reagent;

2-Mammalian Expression Vectors:

A broad array of cloning vectors, that include plasmidic and lentiviral vectors, and CpG-free plasmids, a choice of inducible reporter plasmids, plus an expanding library of human and murine genes, and a wide variety of cellular promoters;

3-Reporter Cells:

A growing collection of functionally validated and mycoplasma-free human and murine cell lines, such as HEK293-, Jurkat-, RAW 264.7- and THP-1-derived cells, that report on one or more pattern recognition receptor (PRR), cytokine, or transcription factor activities using SEAP and/or Lucia luciferase, plus a recently launched line of knockout cells that lack major innate immune sensors or signaling proteins;

4-PRR Ligands:

An expanding collection of agonists and control ligands for all the major PRRs, such as Toll-like receptors (TLRs), NOD-like receptors (NLRs) and cytosolic DNA sensors (CDSs), including ligands of natural and synthetic origin, all screened and validated in-house;

5-Inhibitors:

A wide selection of functionally validated compounds to directly or indirectly block the principal immune (TLR, NLR, CDS) pathways and related signaling pathways;

6-Antibodies and Recombinant Proteins:

A large variety of biologically validated monoclonal and polyclonal antibodies against major human and murine innate immune targets, as well as isotype families of clinically relevant antibodies, plus a selection of recombinant cytokines;

7-Vaccination:

Pre-clinical grade vaccine adjuvants that comprise alum, emulsions, such as CFA and saponin, and PRR ligands, plus various ovalbumin-derived products.

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