HyClone细胞培养产品

公司简介

HyClone自1967年开始为客户提供胎牛血清(FBS)和其它细胞培养产品。2014年3月加入GE医疗后，HyClone继续为客户提供高性能、按照严格质量标准制造的细胞培养产品。HyClone细胞培养产品系列包括血清、培养基、补料、缓冲液和工艺液体。

提升产品品质的先驱

HyClone以客户需求作为产品开发和制造工艺的激励因素，在这方面保持着引以为豪的记录。比如，HyClone是第一家在胎牛血清生产中引入完全真正混合技术的公司，最大限度地降低了血清批次间乃至同批次每瓶之间的差异。随后这种技术成为了无动物源性产品的监管标准。HyClone勤勉尽职地和客户合作，致力于创造满足客户需求的高性能产品。

始终如一的质量和可靠性

GE医疗HyClone产品在严格的质量体系下进行生产，确保始终如一的质量和可靠性。分布在全球关键地区的生产工厂有助于满足不断增长的需求，并保证您能够在世界任何地方、第一时间获得HyClone细胞培养产品。

特色产品

FBS和其它血清

多样化的血清产品，包括胎牛血清(FBS)；其它血清类型包括猪血清和马血清以及血清替代产品。

细胞培养基

经典培养基，经筛选的无血清和化学成分限定培养基，适用于各种细胞系。

缓冲液和工艺液体

简化工艺流程用的质量控制缓冲液和工艺溶液。

补料和细胞培养试剂

培养基优化用的维生素、分离试剂、抗生素和增强细胞培养的补料。

产品类别

ActiPro™ system of media and supplements

• HyClone™ ActiPro system of media and supplements is a high-performing solution designed for a robust bioprocess using Chinese Hamster Ovary (CHO) cells. With an optimized and chemically defined formulation, the system allows clones to reach high viable cell densities fast in batch or fed-batch cultures. ActiPro media and supplements are intended for the industrial production of recombinant proteins, including those requiring complex post-translational modifications and correct protein folding.




Catalog #	Description
SH31037.01	ActiPro powder medium* - 5 L
SH31037.02	ActiPro powder medium† - 10 L
SH31037.05	ActiPro powder medium* - 25 L
SH31039.01	ActiPro liquid medium* - 500 mL
SH31039.02	ActiPro liquid medium* - 1000 mL
SH31039.03	ActiPro liquid medium† - 1 L
SH31038.01	ActiSM powder medium* - 5 L
SH31038.02	ActiSM powder medium† - 10 L
SH31038.05	ActiSM powder medium† - 25 L
SH31040.01	ActiSM liquid medium* - 500 mL
SH31040.02	ActiSM liquid medium* - 1000 mL
SH31040.03	ActiSM liquid medium† - 1 L
SH31026.07	Cell Boost 7a Powder† - 1 L
SH31026.01	Cell Boost 7a Powder† - 5 L
SH31026.02	Cell Boost 7a Powder† - 10 L
SH31026.03	Cell Boost 7a Powder† - 25 L
SH31027.01	Cell Boost 7b Powder* - 0.5 L
SH31027.02	Cell Boost 7b Powder* - 5 L
SH31027.04	Cell Boost 7b Powder† - 10 L
SH31027.07	Cell Boost 7b Powder† - 1 L
SH30034.01	L-glutamine, 200 mM solution (29.2 mg/mL L-glutamine in 0.85% NaCl)* - 100 mL
SH30034.02	L-glutamine, 200 mM solution (29.2 mg/mL L-glutamine in 0.85% NaCl)* - 500 mL
SH30336.03V	L-glutamine, 200 mM solution (29.2 mg/mL L-glutamine in 0.85% NaCl)† - 1000 mL




• Note: Powder product quantity is shown as the final volume after powder reconstitution
• * Stock items
• ^† Item is made to order. Lead times and minimum order quantities apply

Product Overview

• The comprehensive HyClone ActiPro system of media and supplements is an innovative cell culture solution designed for high yields in large-scale protein production in batch or fed-batch cultures using recombinant Chinese hamster ovary (CHO) cells. The ActiPro system is chemically defined with no peptides or hydrolysates, and is animal-derived component-free (ADCF). As the ActiPro media and supplements do not contain hypoxanthine or thymidine (HT), the formulation supports the dihydrofolate reductase (DHFR) gene amplification and selection system. This high-level mammalian expression system employs DHFR-deficient CHO cells in a suspension culture with appropriate metabolite compliments. The ActiPro system is intended for the industrial production of recombinant proteins including those requiring complex post-translational modifications and correct protein folding.

Key features of the ActiPro system of media and supplements

Ready-to-use starter and scale-up kits

Chemically defined ADCF formulation

Does not contain HT, supporting the DHFR system

Regulatory-friendly

High-yield production of complex proteins

Short time to market

ActiPro production medium

• The medium is used for achieving high yield of active protein during cultivation of recombinant CHO cells. Using ActiPro medium with Cell Boost 7a and 7b supplements in fed-batch or perfusion cultures can contribute to significantly increased cell growth and protein yield.
• ActiSM adaptation medium
• ActiSM medium allows the cultivation or adaptation of recombinant CHO cells in small-scale shaker flasks or spinner bottles. This adaptation medium may also be used while working with methotrexate. The lean formulation of ActiSM medium can help simplify and shorten the time-consuming adaptation to fed-batch culture.
• Cell Boost 7a and Cell Boost 7b feed supplements
• Cell Boost 7a and 7b supplements are used as an essential part of a cell culture feed strategy to enhance cell culture performance and increase product yield. Cell Boost 7a and 7b are intended for use together in defined concentrations. Cell Boost 7a and 7b are feed additives especially matched to ActiPro production medium. Combining Cell Boost 7a and 7b has demonstrated significantly increased productivity when compared with batch culture. Established protocols facilitate easy and efficient identification of a feeding strategy. Cell Boost 7a contains concentrated amino acids, vitamins, salts, trace elements, and a carbon source. Cell Boost 7b is a balanced formulation of selected amino acids in a concentrated form.
• High flexibility with the ActiPro system of media and supplements
• Use of the complete ActiPro system of media and supplements helps accelerate the time-consuming fed-batch optimization process. For fast-growing CHO cells with higher carbon consumption, glucose supplementation is needed.

注意事项

*Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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