3000.00
重组人PD-1蛋白(His)(Recombinant Human PD-1 Protein(His))
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重组人PD-1蛋白(His)(Recombinant Human PD-1 Protein(His)),GMP级

产品货号:GMP-TL756


产品描述(Description)

Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.

分子别名(Synonym)

PDCD1、D279、SLEB2

表达宿主(Expression host)

 

HEK293细胞

来源(Source)

Human

蛋白序列(Protein Sequence)

DNA 序列编码人 PD-1( NCBI Reference Sequence: NP_005009.2)表达带有 His 标签在 C 末端

分子量(Molecular Weight)

重组人 PD-1 蛋白包含 148 个氨基酸,预测理论分子量为 21.16kD

纯度(Purity)

≥95%采用SDS-PAGE凝胶和高效液相色谱分析

内毒素(Endotoxin)

<0.1EU/μg

生物活性(Biological Activity)

固定人 PD-1(His 标签)0.5ug/mL (100uL/孔) 能够结合人 PD-L1(Fc 标签) 的线性范围是 0.5-10ug/mL

稳定性(Stability)

冻干的样本的可以在4℃保存24个月,溶解后的液体可以于-20℃保存6-12个月,并且避免反复冻融

组成(Component)

含有6%甘露醇的无菌PBS(PH 7.4)的冻干粉



注意:所有产品仅用于非临床科研用途,不用于诊断、治疗、临床或其他用途

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市场价
3000.00
价格
3000.00
品牌
同立海源
型号
GMP-TL756-100
规格
100ug
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