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Stemcell 72122 IWP-2
Product Overview
IWP-2 inhibits the WNT pathway (IC₅₀ = 27 nM) at the level of the pathway activator Porcupine. Porcupine is a membrane bound acyltransferase that palmitoylates WNT proteins, which leads to WNT secretion and signaling capability. (Chen et al., Willert et al.)
DIFFERENTIATION
· Suppresses self-renewal of mouse embryonic stem (ES) cells and supports their conversion to epiblast-like stem cells (ten Berge et al.).
· Inhibits maintenance and proliferation of mouse Lgr5+ intestinal and cochlear epithelial stem cells, demonstrating the importance of WNT signaling in these processes (Chai et al., Farin et al.).
· Promotes cardiomyocyte differentiation from human pluripotent stem cells (Lian et al., Minami et al.).
CAS Number:686770-61-6
Alternative Names:Inhibitor of WNT Production-2
Chemical Formula:C₂₂H₁₈N₄O₂S₃
Molecular Weight:466.6 g/mol
Purity:≥ 95%
Pathway:WNT
Target:Porcupine
Related products
Description | Catalog # | Format |
IWR-1-endo, 25 mg | 72564 | 25 mg |
IWR-1-endo, 5 mg | 72562 | 5 mg |
IWP-4, 10 mg | 72554 | 10 mg |
IWP-4, 1 mg | 72552 | 1 mg |
IWP-3, 10 mg | 72544 | 10 mg |
IWP-3, 1 mg | 72542 | 1 mg |
IWP-2, 10 mg | 72124 | 10 mg |
IWP-2, 1 mg | 72122 | 1 mg |
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