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Stemcell 72552 IWP-4
Product Overview
Inhibitor of WNT Production-4 (IWP-4) inhibits WNT signaling by inactivating Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating WNT proteins, which is essential for WNT signaling ability and secretion (Chen et al.). IWP-4 impairs WNT pathway activity in vitro with an IC₅₀ value of 25 nM (Chen et al.).
DIFFERENTIATION
· Promotes cardiomyocyte differentiation in human pluripotent stem cells after treatment with CHIR99021 (Lian et al., 2012, 2013; Sequiera et al.).
· Promotes cardiomyocyte differentiation in human embryonic stem cells following primitive streak induction with BMP4 and Activin A (Hudson et al.).
CAS Number:686772-17-8
Alternative Names:Inhibitor of Wnt Production-4
Chemical Formula:C₂₃H₂₀N₄O₃S₃
Molecular Weight:496.6 g/mol
Purity:≥ 95%
Pathway:WNT
Target:Porcupine
Related products
Description | Catalog # | Format |
IWR-1-endo, 25 mg | 72564 | 25 mg |
IWR-1-endo, 5 mg | 72562 | 5 mg |
IWP-4, 10 mg | 72554 | 10 mg |
IWP-4, 1 mg | 72552 | 1 mg |
IWP-3, 10 mg | 72544 | 10 mg |
IWP-3, 1 mg | 72542 | 1 mg |
IWP-2, 10 mg | 72124 | 10 mg |
IWP-2, 1 mg | 72122 | 1 mg |
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