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Stemcell 72564 IWR-1-endo
Product Overview
IWR-1-endo potently inhibits WNT signaling by blocking a cell-based WNT/β-catenin pathway reporter response with an IC₅₀ value of 180 nM (Chen et al.). It inhibits WNT-induced accumulation of β-catenin, through stabilization of the destruction complex member AXIN2 (Chen et al.).
MAINTENANCE AND SELF-RENEWAL
· Promotes self-renewal and maintains pluripotency of human embryonic stem cells and mouse Epi-stem cells when used in combination with CHIR99021 (Kim et al.).
DIFFERENTIATION
· Promotes differentiation of cardiomyocytes from human pluripotent stem cells (PSCs) that have been induced to mesoderm by addition of Activin A and/or BMP4 (Ren et al.; Willems et al.)
· Induces the differentiation of human PSC-derived alveolar epithelial type II (AETII) to AETI cells (Ghaedi et al.).
CAS Number:1127442-82-3
Alternative Names:Not applicable
Chemical Formula:C₂₅H₁₉N₃O₃
Molecular Weight:409.4 g/mol
Purity:≥ 98%
Pathway:WNT
Target:Axin
Related products
Description | Catalog # | Format |
IWR-1-endo, 25 mg | 72564 | 25 mg |
IWR-1-endo, 5 mg | 72562 | 5 mg |
IWP-4, 10 mg | 72554 | 10 mg |
IWP-4, 1 mg | 72552 | 1 mg |
IWP-3, 10 mg | 72544 | 10 mg |
IWP-3, 1 mg | 72542 | 1 mg |
IWP-2, 10 mg | 72124 | 10 mg |
IWP-2, 1 mg | 72122 | 1 mg |
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