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Stemcell  73252  Metformin

Product Overview

Metformin is an activator of the AMP-activated protein kinase (AMPK) pathway, and an inhibitor of mitochondrial respiratory chain complex 1 (Rena et al.; Viollet et al.). It acts as an antihyperglycemic agent to lower plasma glucose levels and improve insulin sensitivity (Viollet et al.). This product is provided as a hydrochloride salt of the molecule.  

DIFFERENTIATION

· Promotes neurogenesis in mouse cortical precursors and human forebrain neural precursors in vitro, and in adult mouse central nervous system in vivo, via activation of the aPKC-CBP pathway (Wang et al.).

METABOLISM

· Stimulates glucose uptake in skeletal muscle and suppresses gluconeogenesis in the liver (Kim et al.; Shaw et al.).

· Reduces fatty liver disease in obese (ob/ob) mice (Lin et al.).

· Inhibits secretion of the adipocyte hormone leptin in mouse brown adipocytes (Klein et al.).

CAS Number:1115-70-4

Alternative Names:Apophage, Diaformin, Fornidd, Glucoformin, Glucophage, LA 6023, Melbin, Orabet, Riomet, Walaphage

Chemical Formula:C₄H₁₁N₅ · HCl

Molecular Weight:165.6 g/mol

Purity:≥ 98%

Pathway:AMPK; 线粒体呼吸链复合物

Target:AMPK

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