1490.00
PD98059, 5 mg
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Stemcell  72174  PD98059

Product Overview

PD98059 is a selective, cell permeable inhibitor of the MEK/ERK pathway that acts by preventing the activation of MEK1 (IC₅₀ = 2 - 7 µM) and MEK2 (IC₅₀ = 50 µM) by upstream kinases. It does not inhibit activated MEK, or the p38 MAPK pathway. (Alessi et al., Davies et al., Dudley et al.)


MAINTENANCE AND SELF-RENEWAL

· Enhances the growth and self-renewal of mouse embryonic stem (ES) cells (Burdon et al., Qi et al.).

· Permits derivation of mouse ES cells from the refractory CBA mouse strain (Buehr and Smith).


DIFFERENTIATION

· Blocks the differentiation of mouse ES cells (Burdon et al.).

· Enhances adipogenic differentiation and blocks osteogenic differentiation of human mesenchymal stem cells (Jaiswal et al.).


CANCER RESEARCH

· Decreases number of AML blast colonies with minimal effect on normal hematopoietic progenitors (Milella et al.).


CAS Number:167869-21-8

Alternative Names:Not applicable

Chemical Formula:C₁₆H₁₃NO₃

Molecular Weight:267.3 g/mol

Purity:≥ 98%

Pathway:MEK/ERK

Target:MEK

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重庆市寰宇安泰生物科技有限公司

市场价
1490.00
价格
1490.00
品牌
StemCell
型号
72174
规格
5 mg
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