Stemcell 72174 PD98059
Product Overview
PD98059 is a selective, cell permeable inhibitor of the MEK/ERK pathway that acts by preventing the activation of MEK1 (IC₅₀ = 2 - 7 µM) and MEK2 (IC₅₀ = 50 µM) by upstream kinases. It does not inhibit activated MEK, or the p38 MAPK pathway. (Alessi et al., Davies et al., Dudley et al.)
MAINTENANCE AND SELF-RENEWAL
· Enhances the growth and self-renewal of mouse embryonic stem (ES) cells (Burdon et al., Qi et al.).
· Permits derivation of mouse ES cells from the refractory CBA mouse strain (Buehr and Smith).
DIFFERENTIATION
· Blocks the differentiation of mouse ES cells (Burdon et al.).
· Enhances adipogenic differentiation and blocks osteogenic differentiation of human mesenchymal stem cells (Jaiswal et al.).
CANCER RESEARCH
· Decreases number of AML blast colonies with minimal effect on normal hematopoietic progenitors (Milella et al.).
CAS Number:167869-21-8
Alternative Names:Not applicable
Chemical Formula:C₁₆H₁₃NO₃
Molecular Weight:267.3 g/mol
Purity:≥ 98%
Pathway:MEK/ERK
Target:MEK
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