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Stemcell 73332 PLX4032
Product Overview
PLX4032 is an ATP-competitive inhibitor of the serine/threonine kinase B-RAF proto-oncogene, with IC₅₀ values of 31 and 100 nM for the wild type and V600E mutant forms respectively (Khazak et al.; Sala et al.).
CANCER RESEARCH
· Inhibits proliferation in colon, melanoma, and thyroid carcinoma cancer cell lines expressing B-RAF V600E, alone or in synergy with Paclitaxil, Vinblastine and Oxaliplatin (Khazak et al.).
· Suppresses MEK and ERK phosphorylation downstream of B-RAF in melanoma cells with mutations at the V600 position, correlated with antiproliferative effects (Joseph et al.; Yang et al.).
· Inhibits tumor growth in B-RAF V600E melanoma tumor xenograft models (Yang et al.).
CAS Number:918504-65-1
Alternative Names:RG-7204, Ro 51-85426, Vemurafenib, Zelboraf™
Chemical Formula:C₂₃H₁₈ClF₂N₃O₃S
Molecular Weight:489.9 g/mol
Purity:≥ 98%
Pathway:MEK/ERK
Target:B-RAF
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