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Stemcell 72204 Purmorphamine
Product Overview
Purmorphamine is a tri-substituted purine derivative that activates the Hedgehog pathway by directly binding to and activating the Hedgehog receptor Smoothened (EC₅₀ = 1 µM). (Sinha and Chen)
DIFFERENTIATION
· Promotes differentiation of ventral spinal progenitors and motor neurons from human pluripotent stem cells (Hu and Zhang, Karumbayaram et al., Li et al.).
· Promotes differentiation of osteoblasts from human and mouse mesenchymal cells (Beloti et al., Wu et al. 2002, Wu et al. 2004).
· Inhibits differentiation and maturation of adipocytes from human mesenchymal cells (Fontaine et al.).
CAS Number:483367-10-8
Alternative Names:Not applicable
Chemical Formula:C₃₁H₃₂N₆O₂
Molecular Weight:520.6 g/mol
Purity:≥ 98%
Pathway:Hedgehog
Target:SMO
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