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Stemcell 72852 Raloxifene
Product Overview
Raloxifene is a selective estrogen receptor modulator (SERM) that exhibits agonistic (estrogenic) activity in bone cells without stimulating ER activity in breast or uterine tissues (Black et al.).
DIFFERENTIATION
· Enhances osteoblast differentiation in mouse bone marrow and human osteoblast cultures (Qu et al.; Viereck et al.).
· Inhibits osteoclast differentiation in primary human bone marrow mononuclear cell cultures (Ramalho et al.).
· Reduced endodermal differentiation (HNF-4α expression) in embryoid bodies derived from human embryonic stem (ES) cells (Kim et al.).
CAS Number:82640-04-8
Alternative Names:Evista®; Keoxifene; LY156758
Chemical Formula:C₂₈H₂₇NO₄S · HCl
Molecular Weight:510.2 g/mol
Purity:≥ 98%
Pathway:雌激素
Target:ER
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