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Stemcell 73362 Rapamycin
Product Overview
Rapamycin is a macrolide antibiotic and immunosuppressive compound that inhibits mammalian target of rapamycin (mTOR) signaling. It acts through formation of a complex with cytosolic FK-binding protein 12 (FKBP-12), which directly binds to mTOR complex 1 (mTORC1). Its immunosuppressive effects are mediated through inhibition of IL-2 signaling that is critical for T-cell proliferation and activation (Gibbons et al.; Kay et al.). Rapamycin shows antifungal activity against Candida albicans and other fungi (Vézina et al.)
CANCER RESEARCH
· Inhibits growth of MDA-MB-468 human breast cancer cells in vitro, and inhibits tumor growth in a mouse xenograft model in vivo (Akcakanat et al.).
· Induces autophagy in malignant glioma cells (Takeuchi et al.).
CAS Number:53123-88-9
Alternative Names:AY 22989, Cypher, NSC 226080, Sirolimus
Chemical Formula:C₅₁H₇₉NO₁₃
Molecular Weight:914.2 g/mol
Purity:≥ 95%
Pathway:mTOR
Target:FKBP-12
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