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Stemcell 72632 SB202190
Product Overview
SB202190 is a selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC₅₀ values of 50 and 100 nM, respectively (Davies et al.; Jiang et al.). As a pyridinyl imidazole inhibitor, SB202190 directly binds p38 MAP kinases in the ATP binding pocket (Fox et al.).
MAINTENANCE AND SELF-RENEWAL
· Improves the self-renewal ability of neural stem cells from NPC1-deficient mice (Yang et al.).
· Blocks adiponectin-mediated proliferation of hematopoietic stem cells (DiMascio et al.).
· Reduces BMP3-mediated proliferation of C3H10T1/2 mesenchymal stem cells (Stewart et al.).
DIFFERENTIATION
· Induces cardiomyocyte differentiation from human embryonic stem cells (Graichen et al.).
CAS Number:152121-30-7
Alternative Names:Not applicable
Chemical Formula:C₂₀H₁₄FN₃O
Molecular Weight:331.3 g/mol
Purity:≥ 98%
Pathway:p38 MAPK
Target:p38 MAPK
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