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Stemcell 72222 SB203580
Product Overview
SB203580 (Hydrochloride) is a potent inhibitor of p38 MAPK activity (IC₅₀ = 0.6 µM). It inhibits both the α and β isoforms of p38 MAPK, and does not inhibit ERK or JNK. (Bain et al., Cuenda et al.)
MAINTENANCE AND SELF-RENEWAL
· Enhances the growth and self-renewal of mouse embryonic stem (ES) cells (Qi et al.).
· Promotes long-term maintenance of human naïve ground state pluripotent stem cells (Gafni et al.).
· Promotes proliferation of human endothelial progenitor cells (Seeger et al.).
· Promotes proliferation of neonatal and adult rat cardiomyocytes (Engel et al.).
DIFFERENTIATION
· Enhances differentiation of cardiomyocytes from human ES cells (Gaur et al., Graichen et al.).
· Inhibits differentiation of cardiomyocytes from mouse ES cells by inhibition of early mesoderm (Davidson and Morange).
CAS Number:869185-85-3
Alternative Names:PB 203580; RWJ 64809
Chemical Formula:C₂₁H₁₆FN₃OS · HCl
Molecular Weight:413.9 g/mol
Purity:≥ 98%
Pathway:p38 MAPK
Target:p38 MAPK
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