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Stemcell 73432 SU11274
Product Overview
SU11274 is a selective, ATP-competitive inhibitor of MET receptor tyrosine kinase (IC₅₀ = 20 nM; Sattler et al.). It shows good selectivity towards MET versus other receptor tyrosine kinases with IC₅₀ values of 1.3 μM and 9.7 μM for kinase insert domain receptor (KDR) and fibroblast growth factor receptor-1 (FGFR1), respectively (Sattler et al.). It retains activity for certain MET mutants, for example H1112Y and M1268T (Berthou et al.).
CANCER RESEARCH
· Induces apoptosis and cell cycle arrest in TPR-MET-transformed mouse pre-B (Ba/F3) cells (Sattler et al.).
· Inhibits cell viability and motility of human head and neck squamous cell carcinoma cell lines in vitro (Seiwert et al.).
· Inhibits cell viability of c-MET-expressing human non-small cell lung carcinoma cell lines in vitro (Ma et al.).
CAS Number:658084-23-2
Alternative Names:Met Kinase Inhibitor
Chemical Formula:C₂₈H₃₀ClN₅O₄S
Molecular Weight:568.1 g/mol
Purity:≥ 98%
Pathway:HGF
Target:MET
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