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Stemcell 72662 Tamoxifen
Product Overview
Tamoxifen is a selective estrogen receptor modulator (SERM), with tissue-specific antagonistic or agonistic effects. Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription. Tamoxifen is commonly used to conditionally activate Cre-ER in transgenic models.
CELL LINE DEVELOPMENT
· Used in transgenic models to induce Cre-mediated recombination in conjunction with Cre-ER, a fusion protein consisting of Cre recombinase and a mutant form of the estrogen receptor hormone-binding domain that specifically binds tamoxifen but not estrogen (Zhang et al.; Feil et al.).
CANCER RESEARCH
· Inhibits growth in the human breast cancer cell line, MCF-7 (Katzenellenbogen et al.).
· Antagonist of estrogen receptor action in breast tissue and breast cancer cells (Abe et al.; Horwitz et al.).
CAS Number:10540-29-1
Alternative Names:Not applicable
Chemical Formula:C₂₆H₂₉NO
Molecular Weight:371.5 g/mol
Purity:≥ 95%
Pathway:雌激素
Target:ER
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