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Stemcell 72254 Thiazovivin
Product Overview
Thiazovivin is a selective inhibitor of Rho-associated coiled-coil containing protein kinase (ROCK), a serine/threonine kinase that plays a role in cell polarity, contraction, and actin cytoskeleton reorganization. (Xu et al.)
REPROGRAMMING
· Increases the efficiency of reprogramming human somatic cells to iPS cells, in combination with PD0325091 and SB431542 (Lin et al.).
· Increases the efficiency of reprogramming human cord blood mononuclear cells to iPS cells (Hu et al.).
MAINTENANCE AND SELF-RENEWAL
· Promotes survival of human embryonic stem (ES) cells during dissociation by stabilizing E-cadherin and improves cell attachment (Xu et al.).
· Promotes survival of single human induced pluripotent stem (iPS) cells during transfection for TALEN-mediated genome editing (Sun and Zhao).
CAS Number:1226056-71-8
Alternative Names:Tzv
Chemical Formula:C₁₅H₁₃N₅OS
Molecular Weight:311.4 g/mol
Purity:≥ 98%
Pathway:RHO/ROCK
Target:ROCK
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