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Stemcell 73494 Torin 1
Product Overview
Torin 1 is an ATP-competitive inhibitor of the mammalian target of rapamycin (mTOR), inhibiting the mTOR complexes mTORC1 and mTORC2 with IC₅₀ values of 2 and 10 nM respectively. It is selective for mTOR versus a panel of over 400 other kinases screened at 10 µM (Thoreen et al.; Liu et al.).
CANCER RESEARCH
· Inhibits tumor growth, likely through a cytostatic rather than cytotoxic mechanism, in a U87MG PTEN-null glioblastoma mouse xenograft model (Liu et al.).
· Hinders growth, motility, invasion, and survival of primary colon cancer stem-like cells in vitro, and suppresses tumor growth but does not affect normal colon stem cells in xenografts (Francipane & Lagasse).
CAS Number:1222998-36-8
Alternative Names:Not applicable
Chemical Formula:C₃₅H₂₈F₃N₅O₂
Molecular Weight:607.6 g/mol
Purity:≥ 95%
Pathway:mTOR
Target:mTOR
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