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Stemcell 72274 Tranylcypromine
Product Overview
Tranylcypromine is an epigenetic modifier that is an irreversible inhibitor of Lysine-Specific Demethylase 1 (LSD1, IC₅₀ = 20.7 µM). The catalytic site of LSD1 shares similarity with monoamine oxidase (MAO) enzymes and Tranylcypromine also inhibits MAO A (IC₅₀ = 2.3 µM) and MAO B (IC₅₀ = 0.95 µM). (Lee et al., Schmidt and McCafferty)
REPROGRAMMING
· Enables chemical reprogramming (without genetic factors) of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells, in combination with CHIR99021, Forskolin, Valproic Acid, 3-Deazaneplanocin A, and E-616452 (Hou et al.).
· Promotes reprogramming of human keratinocytes to iPS cells using only 2 factors (OCT4 and KLF4), in combination with CHIR99021 (Li et al.).
· Converts mouse epiblast-like stem cells to a more primitive embryonic stem (ES)-like state, in combination with several other small molecules (Zhou et al.).
MAINTENANCE AND SELF-RENEWAL
· Inhibits proliferation of mouse neural stem cells (Sun et al.).
·Blocks differentiation of mouse ES cells as well as the differentiation-induced demethylation of ES-specific enhancers (Whyte et al.).
CAS Number:1986-47-6
Alternative Names:2-PCPA hydrochloride; Parnate; Trans-2-Phenylcyclopropylamine hydrochloride
Chemical Formula:C₉H₁₁N · HCl
Molecular Weight:169.7 g/mol
Purity:≥ 98%
Pathway:Epigenetic
Target:Histone Demethylase
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